Porcelain gallbladder and its relationship to cancer

Summary Background Porcelain gallbladder (PGB) is defined as calcium deposits encrusting the internal visceral layer, which becomes hard, brittle, and bluish. rare has been found in less than 1% of routine cholecystectomy specimens. Several studies report an incidence carcinoma (GBC) associated with calcification varying between 12.5 61%, data have known for 60 years. There a lack information concerning PGB its association GBC, aim this study to better define relationship. Methods A total 10 patients were 1050 consecutive surgical cholecystectomies. Clinical laboratory findings, histologic examination, bile culture, pH related stone composition analysis performed by X‑ray diffraction using Perkin–Elmer (Perkin Elmer Corp. Norwalk, CT, US) 1625 FTIR. Results Among PGB, complete entire wall was present six cases, while four had partial calcification. Gallstones all cases multiple stones nine single one case. Bile culture series. positive two cases. Conclusion disease it subtle. Moreover, chronic stimulation can generate initial dysplasia that will subsequently turn into neoplasm: cancerization risk probably no different from long-standing cholesterol or combined stones, but factor cancer requires early cholecystectomy.